Pharmacy Times CE: Drug Interactions with Grapefruit Juice: An Evidence-Based Overview
نویسندگان
چکیده
1 Identify the mechanism of grapefruit juice-drug interactions and drugs involved with significant grapefruit-drug interactions. 2 Describe potential effects of grapefruit juice-drug interactions.. 3 Discuss medications that may be affected and degree of risk associated with common interacting medications.. 4 Identify effective alternative medications that do not interact (for patients who do not want to comply with dietary restrictions).. 5 Articulate the public health implications of media myths and inaccurate information surrounding this issue.. 6 Describe the pharmacist's role in communication the food-drug interaction issue to patients and physicians.. 7 Effectively explain drug interaction risk factors and effective, alternative medications for patients.
منابع مشابه
Double-whammy: Food-drug Interactions Components in Grapefruit and Other Foods May Dramatically Affect Absorption and Metabolism of Therapeutic Drugs
29-year-old man, who had been taking a prescription allergy medication, twice a day, for over a year, drank two glasses of grapefruit juice with his medication and went out to mow the lawn. Suddenly, he became ill, stumbled into his home and collapsed. The coroner found that the man had died of irregular heartbeats caused by drug toxicity. Because of the deadly consequences of this allergy medi...
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Because grapefruit contains fibre, vitamin C, antioxidants and phytochemicals, the fruit and its juice are consumed widely to help meet daily nutritional requirements. However, in the past 15 years, studies have shown that grapefruit juice can induce a several-fold increase in the plasma levels of particular drugs that can result in increased therapeutic or even toxic effects. The effect seems ...
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The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
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Grapefruit juice elevates blood levels of some drugs taken orally, primarily by inhibiting intestinal CYP3A4-mediated first-pass metabolism. Two prominent furanocoumarins in the juice, 6',7'-dihydroxybergamottin (DHB) and bergamottin (BG), have been demonstrated as important contributors to grapefruit juice-drug interactions. Using CYP3A4-expressing Caco-2 cells and representative probes from d...
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